CareLit · DOI-Nachweis · Klinische Pädiatrie
Hedgehog Signaling: A Therapeutic Target in Embryonal Rhabdomyosarcoma?
DOI 10.1055/s-0030-1270305
Bibliografische Angaben
Nachweis in CareLit
Autor:innenH Hahn, F Nitzki, A Zibat, A Uhmann, I Ecke, A Rosenberger, O Witt, W Schulz-Schaeffer
ZeitschriftKlinische Pädiatrie
Ausgabe12/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, occurs in two major histological subtypes, embryonal (ERMS) and alveolar (ARMS). Aberrant Hedgehog (Hh) signalling due to germline mutations in the Hh receptor Patched (Ptch) has been linked to ERMS. Our goal is to better understand the role of this pathway in the pathogenesis of RMS, and to test it as a therapeutic target. Sixty per-cent of he…
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Zitierempfehlung
H Hahn, F Nitzki, A Zibat, A Uhmann, I Ecke, A Rosenberger, O Witt, W Schulz-Schaeffer (2010) Hedgehog Signaling: A Therapeutic Target in Embryonal Rhabdomyosarcoma?. Klinische Pädiatrie (12). https://doi.org/10.1055/s-0030-1270305
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