CareLit · DOI-Nachweis · Klinische Pädiatrie
The KidsCancerKinome: Validation of Cell Cycle Genes as Potential Drug Targets in Pediatric Tumors
DOI 10.1055/s-0030-1270311
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJJ Molenaar, EM Westerhout, ML Den Boer, SC Clifford, O Delattre, B Geoerger, C Lanvers, T Pietsch, M Serra, J Shipley, G Vassal, R Versteeg, AC Verschuur, HN Caron
ZeitschriftKlinische Pädiatrie
Ausgabe12/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The KCK consortium has validated CDK2 as potential drug target in six highly malignant pediatric tumor types (i.e Ewing sarcoma, osteosarcoma, rhabdomyosarcoma, neuroblastoma, medulloblastoma and ALL). The stepwise procedure started with the selection of genes that can be targeted using small molecule inhibitors. Drug target genes and signal transduction routes were studied using Affymetrix mRNA profiles of over 500…
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Zitierempfehlung
JJ Molenaar, EM Westerhout, ML Den Boer, SC Clifford, O Delattre, B Geoerger, C Lanvers, T Pietsch, M Serra, J Shipley, G Vassal, R Versteeg, AC Verschuur, HN Caron (2010) The KidsCancerKinome: Validation of Cell Cycle Genes as Potential Drug Targets in Pediatric Tumors. Klinische Pädiatrie (12). https://doi.org/10.1055/s-0030-1270311
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