CareLit · DOI-Nachweis · Klinische Pädiatrie
Targeting IAP Proteins to Sensitize Childhood Acute Leukemia Cells for Apoptosis
DOI 10.1055/s-0030-1270325
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Fakler, S Löder, M Vogler, K Schneider, I Jeremias, KM Debatin, S Fulda
ZeitschriftKlinische Pädiatrie
Ausgabe12/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
XIAP, a member of „Inhibitor of Apoptosis“ (IAP) proteins, may present a suitable molecular target for therapeutic intervention, since it is expressed at high levels in acute leukemia and blocks apoptosis at a central point of the apoptotic machinery. Here, we report that neutralizing XIAP by small molecule inhibitors is a novel and effective approach to sensitize childhood acute leukemia cells for TRAIL-induced apo…
Zitieren
Zitierempfehlung
M Fakler, S Löder, M Vogler, K Schneider, I Jeremias, KM Debatin, S Fulda (2010) Targeting IAP Proteins to Sensitize Childhood Acute Leukemia Cells for Apoptosis. Klinische Pädiatrie (12). https://doi.org/10.1055/s-0030-1270325
Mit CareLit weiterarbeiten