CareLit · DOI-Nachweis · Klinische Pädiatrie
Hsa-mir-125b-2 is Highly Expressed in Childhood ETV6/RUNX1 (TEL/AML1) Leukemias and Confers Survival Advantage to Growth Inhibitory Signals Independent of P53
DOI 10.1055/s-0030-1270330
Bibliografische Angaben
Nachweis in CareLit
Autor:innenV Binder
ZeitschriftKlinische Pädiatrie
Ausgabe12/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
MicroRNAs (miRNAs) regulate the expression of multiple proteins in a dose-dependent manner. We hypothesized that increased expression of miRNAs encoded on chromosome 21 (chr 21) contribute to the leukemogenic role of trisomy 21. The levels of chr 21 miRNAs were quantified by qRT-PCR in four types of childhood ALL characterized by either numerical (trisomy or tetrasomy) or structural abnormalities of chr 21. Surprisi…
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Zitierempfehlung
V Binder (2010) Hsa-mir-125b-2 is Highly Expressed in Childhood ETV6/RUNX1 (TEL/AML1) Leukemias and Confers Survival Advantage to Growth Inhibitory Signals Independent of P53. Klinische Pädiatrie (12). https://doi.org/10.1055/s-0030-1270330
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