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The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia1

M Witzenrath, F Pache, D Lorenz, U Koppe, B Gutbier, K Meixenberger, C Tabeling, A Dorhoi, J Ma, A Holmes, G Trendelenburg, MM Heimesaat, S Bereswill, M van der Linden, J Tschopp, TJ Mitchell, N Suttorp, B Opitz · Pneumologie · Ausgabe 02/2011

DOI 10.1055/s-0030-1270363

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Autor:innenM Witzenrath, F Pache, D Lorenz, U Koppe, B Gutbier, K Meixenberger, C Tabeling, A Dorhoi, J Ma, A Holmes, G Trendelenburg, MM Heimesaat, S Bereswill, M van der Linden, J Tschopp, TJ Mitchell, N Suttorp, B Opitz
ZeitschriftPneumologie
Ausgabe02/2011
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Streptococcus pneumoniae is a leading cause of pneumonia, meningitis and sepsis. While certain pneumococcal serotypes are associated with nasopharyngeal colonization, infections in patients with underlying diseases, and higher mortality when causing pneumonia, serotypes 1, 7F and 8 are predominantly found in invasive diseases that, however, show lower case-fatality rates. We tested the hypotheses that the innate imm…

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Zitierempfehlung

M Witzenrath, F Pache, D Lorenz, U Koppe, B Gutbier, K Meixenberger, C Tabeling, A Dorhoi, J Ma, A Holmes, G Trendelenburg, MM Heimesaat, S Bereswill, M van der Linden, J Tschopp, TJ Mitchell, N Suttorp, B Opitz (2011) The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia1. Pneumologie (02). https://doi.org/10.1055/s-0030-1270363

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