CareLit · DOI-Nachweis · Pneumologie
Influence of the endothelin receptor antagonists Ambrisentan and Bosentan on TNFa induced GM-CSF expression in human airway smooth muscle cells
DOI 10.1055/s-0030-1270367
Bibliografische Angaben
Nachweis in CareLit
Autor:innenD Jungck, J Knobloch, K Urban, J Strauch, E Stoelben, A Koch
ZeitschriftPneumologie
Ausgabe02/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Human airway smooth muscle cells (HASMCs) have an important part in chronic inflammatory airway diseases and lung fibrosis for whose establishment TNFα and GM-CSF have a key role. We were able to show TNFα induced GM-CSF expression is regulated by endothelin-1 (ET-1) (Thorax, 2009;64:1044–52). This hints at an anti-inflammatory effect of endothelin receptor antagonists (ERA). Their efficacy in idiopathic…
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Zitierempfehlung
D Jungck, J Knobloch, K Urban, J Strauch, E Stoelben, A Koch (2011) Influence of the endothelin receptor antagonists Ambrisentan and Bosentan on TNFa induced GM-CSF expression in human airway smooth muscle cells. Pneumologie (02). https://doi.org/10.1055/s-0030-1270367
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