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Effects of multi-kinase inhibitors on pulmonary vascular and right ventricular remodelling

B Kojonazarov, A Sydykov, H Luitel, D Kosanovic, S Pullamsetti, X Tian, S Evans, P Phillips, N Davie, N Weissmann, F Grimminger, W Seeger, HA Ghofrani, RT Schermuly · Pneumologie · Ausgabe 03/2011

DOI 10.1055/s-0031-1272117

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Autor:innenB Kojonazarov, A Sydykov, H Luitel, D Kosanovic, S Pullamsetti, X Tian, S Evans, P Phillips, N Davie, N Weissmann, F Grimminger, W Seeger, HA Ghofrani, RT Schermuly
ZeitschriftPneumologie
Ausgabe03/2011
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Background: Inhibition of receptor tyrosine kinases has been shown to improve experimental pulmonary hypertension (PH) and PAH in patients. However, little is known about the effects of current PAH therapies including receptor tyrosine kinase inhibitors on heart remodeling. Aim of this study was to investigate the effects of the multikinase inhibitors sunitinib and sorafenib on right ventricular (RV) remodeling. Met…

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B Kojonazarov, A Sydykov, H Luitel, D Kosanovic, S Pullamsetti, X Tian, S Evans, P Phillips, N Davie, N Weissmann, F Grimminger, W Seeger, HA Ghofrani, RT Schermuly (2011) Effects of multi-kinase inhibitors on pulmonary vascular and right ventricular remodelling. Pneumologie (03). https://doi.org/10.1055/s-0031-1272117

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