CareLit · DOI-Nachweis · Pneumologie
Abl tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages
DOI 10.1055/s-0031-1272263
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Stenger, H Bruns, F Stegelmann, K Döhner, G van Zandbergen, JH Ficker, M Wagner
ZeitschriftPneumologie
Ausgabe03/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The mechanisms that regulate the acidification of intracellular compartments are key to host defense pathways against intracellular pathogens. Here we demonstrate that Abl tyrosine kinase, a master switch for cell growth, cell survival and trafficking of organelles, controls the acidification of lysosomes and phagosomes. Inhibition of Abl tyrosine kinase by imatinib, a molecular targeted therapy used as standard tre…
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Zitierempfehlung
S Stenger, H Bruns, F Stegelmann, K Döhner, G van Zandbergen, JH Ficker, M Wagner (2011) Abl tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages. Pneumologie (03). https://doi.org/10.1055/s-0031-1272263
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