CareLit · DOI-Nachweis · Pneumologie
Superoxide generation by NOX1 contributes to abnormal migration and proliferation of pulmonary arterial smooth muscle cells in rats
DOI 10.1055/s-0031-1272324
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Nachweis in CareLit
Autor:innenF Veit, M Roth, B Egemnazarov, M Seimetz, HA Ghofrani, RT Schermuly, W Seeger, F Grimminger, N Weissmann
ZeitschriftPneumologie
Ausgabe03/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Rationale: Chronic alveolar hypoxia induces pulmonary hypertension (PH), concomitant with pulmonary vascular remodeling. Reactive oxygen species (ROS) are thought to play a major role in this process. Our recent findings suggest that ROS production by NAD(P)H-oxidase 4 (NOX4) is important in this remodeling process. Objectives: We investigated whether similar mechanisms are true for non-hypoxia induced PH, namely PH…
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Zitierempfehlung
F Veit, M Roth, B Egemnazarov, M Seimetz, HA Ghofrani, RT Schermuly, W Seeger, F Grimminger, N Weissmann (2011) Superoxide generation by NOX1 contributes to abnormal migration and proliferation of pulmonary arterial smooth muscle cells in rats. Pneumologie (03). https://doi.org/10.1055/s-0031-1272324
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