CareLit · DOI-Nachweis · Klinische Neurophysiologie
Targeting the p53 tumor suppressor activity in glioblastomas using small molecule MDM2-inhibitor
DOI 10.1055/s-0031-1272660
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Autor:innenP. Monfared, T. Viel, G. Schneider, Y. Waerzeggers, S. Rapic, B. Neumaier, H. Backes, A. Winkeler, A.H. Jacobs
ZeitschriftKlinische Neurophysiologie
Ausgabe03/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Targeted therapies that inhibit the MDM2-p53 interaction and the downstream RB-E2F signalling pathway have shown promising antitumor activity, but their efficacy in gliomas has not been investigated. Small-molecule MDM2 antagonists have been developed to specifically inhibit the MDM2-p53 interaction, thereby activating p53 signalling serving anti-tumor activity. Aims: To investigate the therapeutic pot…
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Zitierempfehlung
P. Monfared, T. Viel, G. Schneider, Y. Waerzeggers, S. Rapic, B. Neumaier, H. Backes, A. Winkeler, A.H. Jacobs (2011) Targeting the p53 tumor suppressor activity in glioblastomas using small molecule MDM2-inhibitor. Klinische Neurophysiologie (03). https://doi.org/10.1055/s-0031-1272660
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