CareLit · DOI-Nachweis · Klinische Neurophysiologie
Potassium channel modulation – a therapeutic principle? 4-Aminopyridine in autoimmune central nervous system disease
DOI 10.1055/s-0031-1272710
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK. Göbel, H. Wiendl, T. Budde, S.G. Meuth
ZeitschriftKlinische Neurophysiologie
Ausgabe03/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
4-Aminopyridine (4-AP) is a potassium channel blocking agent. Electrophysiologic studies of demyelinated axons have shown that augmented potassium currents increase extracellular potassium ion concentrations which decrease action potential duration and amplitude which may cause conduction failure. Potassium channel blockade might reverse this effect and could therefore be neuroprotective in autoimmune disorders of t…
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Zitierempfehlung
K. Göbel, H. Wiendl, T. Budde, S.G. Meuth (2011) Potassium channel modulation – a therapeutic principle? 4-Aminopyridine in autoimmune central nervous system disease. Klinische Neurophysiologie (03). https://doi.org/10.1055/s-0031-1272710
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