CareLit · DOI-Nachweis · Klinische Pädiatrie
Glucocorticoid resistance may be implicated in the emergence of ETV6/RUNX1- positive relapses
DOI 10.1055/s-0031-1277062
Bibliografische Angaben
Nachweis in CareLit
Autor:innenR Grausenburger, L Kuster, A Inthal, R Panzer-Grümayer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Although ETV6/RUNX1 (E/R)-positive ALL is generally associated with excellent treatment response, up to 20% of cases suffer a relapse. To gain insight into relapse mechanisms we analyzed genome-wide copy number aberrations in 18 matched diagnosis and relapse leukemias. Strikingly, we identified recurrent deletions of genes implicated in glucocorticoid (GC) mediated apoptosis affecting NR3C1 and BMF encoding the GC r…
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Zitierempfehlung
R Grausenburger, L Kuster, A Inthal, R Panzer-Grümayer (2011) Glucocorticoid resistance may be implicated in the emergence of ETV6/RUNX1- positive relapses. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0031-1277062
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