CareLit · DOI-Nachweis · Klinische Pädiatrie
Acetylation of p53 is involved in VPA induced death of AML cells
DOI 10.1055/s-0031-1277066
Bibliografische Angaben
Nachweis in CareLit
Autor:innenT Dittrich, D Reinhardt, K Welte, JH Klusmann, BK Thakur
ZeitschriftKlinische Pädiatrie
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Histone deacetylases (HDACs) coordinate complex expression patterns by removing acetyl groups from histone and non-histone proteins. Impaired acetylation level, due to increased HDAC activity often relates to pathological malignancies. Thus, efforts have been made to find compounds that inhibit HDAC activity, hence modifying cellular signalling pathways relevant for leukemogenesis. The anticonvulsant valproic acid (…
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Zitierempfehlung
T Dittrich, D Reinhardt, K Welte, JH Klusmann, BK Thakur (2011) Acetylation of p53 is involved in VPA induced death of AML cells. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0031-1277066
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