CareLit · DOI-Nachweis · Klinische Pädiatrie
Gene expression-based chemical genomics identifies VPA to revert the oncogenic effect of GATA1s in Down syndrome leukemia
DOI 10.1055/s-0031-1277067
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Nachweis in CareLit
Autor:innenK Heitmann, BK Thakur, Z Li, J Schöning, JP Bourquin, D Reinhardt, SH Orkin, JH Klusmann
ZeitschriftKlinische Pädiatrie
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Acquired mutations in the hematopoietic transcription factor GATA1 (GATA1s), are consistently present in Down syndrome acute megakaryoblastic leukemia (DS-AMKL) and the antecedent transient leukemia. Truncated GATA1s fails to directly interact and repress E2F activators to coordinate proliferation and terminal megakaryocytic differentiation. Methods: To develop novel targeted and less toxic treatment o…
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Zitierempfehlung
K Heitmann, BK Thakur, Z Li, J Schöning, JP Bourquin, D Reinhardt, SH Orkin, JH Klusmann (2011) Gene expression-based chemical genomics identifies VPA to revert the oncogenic effect of GATA1s in Down syndrome leukemia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0031-1277067
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