CareLit · DOI-Nachweis · Klinische Pädiatrie
Modulation of the p53 pathway by ETV6/RUNX1 in childhood ALL
DOI 10.1055/s-0031-1277070
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Nachweis in CareLit
Autor:innenU Kaindl, M Morak, G Fuka, G Krapf, R Panzer-Grümayer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The t(12;21) is the most frequent translocation in childhood acute lymphoblastic leukemia generating the ETV6/RUNX1 (E/R) fusion gene. This fusion gene confers survival advantage and leads to clonal expansion of a preleukemic clone. It is, however, unable to generate overt leukemia by itself. Based on previous data suggesting that E/R interferes with p53 function, we investigated this issue further. p53 is a central…
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Zitierempfehlung
U Kaindl, M Morak, G Fuka, G Krapf, R Panzer-Grümayer (2011) Modulation of the p53 pathway by ETV6/RUNX1 in childhood ALL. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0031-1277070
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