CareLit · DOI-Nachweis · Klinische Pädiatrie
Functional Genomics: Identification of Potential Oncogenes on Chromosome 21 by RNA Interference Screening
DOI 10.1055/s-0031-1277072
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Autor:innenVR Thangapandi, ML Koch, D Reinhardt, JH Klusmann
ZeitschriftKlinische Pädiatrie
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Down syndrome acute megakaryoblastic leukemia (DS-AMKL) is characterized by the triad of fetal origin, mutated GATA1 (GATA1s), and trisomy 21. Methods: Hypothesizing that the presence of an extra copy of human chromosome 21 (hsa21) is one basal requirement for the onset of the DS-AMKL, we sought to screen for potential oncogenic candidates using a lentiviral shRNA library (522 shRNA constructs against…
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Zitierempfehlung
VR Thangapandi, ML Koch, D Reinhardt, JH Klusmann (2011) Functional Genomics: Identification of Potential Oncogenes on Chromosome 21 by RNA Interference Screening. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0031-1277072
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