CareLit · DOI-Nachweis · Klinische Pädiatrie
D-L1 blockade effectively restores strong graft-versus-leukemia effects without graft- versus-host-disease after delayed adoptive transfer of T cell receptor gene-engineered allogeneic CD8+ T cells
DOI 10.1055/s-0031-1277075
Bibliografische Angaben
Nachweis in CareLit
Autor:innenW Koestner, M Hapke, J Herbst, C Klein, K Welte, J Fruehauf, A Flatley, DA Vignali, M Hardtke-Wolenski, E Jaeckel, BR Blazar, MG Sauer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Adoptive transfer (AT) of T cells forced to express tumor-reactive T cell receptor (TCR) genes is an attractive strategy to direct autologous T cell immunity against tumor-associated antigens (TAAs). However, clinical effectiveness has been hampered by limited in vivo persistence. We investigated whether the use of MHC-mismatched T cells would prolong the in vivo persistence of tumor-reactive TCR gene expressing T c…
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Zitierempfehlung
W Koestner, M Hapke, J Herbst, C Klein, K Welte, J Fruehauf, A Flatley, DA Vignali, M Hardtke-Wolenski, E Jaeckel, BR Blazar, MG Sauer (2011) D-L1 blockade effectively restores strong graft-versus-leukemia effects without graft- versus-host-disease after delayed adoptive transfer of T cell receptor gene-engineered allogeneic CD8+ T cells. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0031-1277075
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