CareLit · DOI-Nachweis · Klinische Pädiatrie
The role of DNA methylation at CTCF binding sites in the regulation of WT1 and NNAT in Wilms tumor
DOI 10.1055/s-0031-1277084
Bibliografische Angaben
Nachweis in CareLit
Autor:innenF Zitzmann, D von Schweinitz, J Müller-Höcker, R Kappler, J Hubertus
ZeitschriftKlinische Pädiatrie
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Epigenetic alterations are suspected to play a critical role in the development and prognosis of embryonal tumors. Best examined examples for aberrant DNA methylation in Wilms tumor is loss of imprinting at the IGF2-H19 locus. Recently, it was discovered that hypermethylation of CTCF binding sites within the IGF2-H19 locus leads to inability of CTCF to insulate IGF2 from a downstream enhancer resulting…
Zitieren
Zitierempfehlung
F Zitzmann, D von Schweinitz, J Müller-Höcker, R Kappler, J Hubertus (2011) The role of DNA methylation at CTCF binding sites in the regulation of WT1 and NNAT in Wilms tumor. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0031-1277084
Mit CareLit weiterarbeiten