CareLit · DOI-Nachweis · Klinische Pädiatrie
Descriptive and functional analysis of amplified genome regions in primary human neuroblastoma and human neuroblastoma cell lines
DOI 10.1055/s-0031-1277088
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Till, A Weber, S Starke, NM Christiansen, H Christiansen
ZeitschriftKlinische Pädiatrie
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: A strong predictor of poor prognosis in neuroblastoma (NB) is the amplification of the oncogene MYCN. MYCN is a transcription factor that regulates target genes, which affect processes like cell cycle, differentiation and apoptosis. Methods and results: As a model system for gene amplification we use the dhfr-gen, which is amplified in cells in response to exposure to methotrexat (MTX). The activation…
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Zitierempfehlung
S Till, A Weber, S Starke, NM Christiansen, H Christiansen (2011) Descriptive and functional analysis of amplified genome regions in primary human neuroblastoma and human neuroblastoma cell lines. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0031-1277088
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