CareLit · DOI-Nachweis · Klinische Pädiatrie
Targeted siRNA delivery to myeloid precursor cells
DOI 10.1055/s-0031-1277093
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Beyerle, R Rueger, A Scholz, R Kontermann, O Heidenreich
ZeitschriftKlinische Pädiatrie
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
RNA interference (RNAi) provides a new way to target „undruggable sides“ of the body for several kind of diseases, e.g. leukaemia. Several fusion proteins are indispensable for the maintenance of leukaemic growth both in vitro and in vivo. Therefore, we introduced an antibody-conjugated immunoliposomes which deliver siRNAs to leukaemic cells and subsequently downregulated the targeted fusion gene of AML1/MTG8. Diffe…
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Zitierempfehlung
A Beyerle, R Rueger, A Scholz, R Kontermann, O Heidenreich (2011) Targeted siRNA delivery to myeloid precursor cells. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0031-1277093
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