CareLit · DOI-Nachweis · Klinische Pädiatrie
Development of an IL-21 enhanced MYCN-DNA vaccine for anti-neuroblastoma immunotherapy
DOI 10.1055/s-0031-1277095
Bibliografische Angaben
Nachweis in CareLit
Autor:innenD Reker, A Stermann, N Huebener, F Westermann, N Siebert, HN Lode
ZeitschriftKlinische Pädiatrie
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: MYCN amplification and subsequent overexpression is associated with an aggressive and chemotherapy-resistant neuroblastoma (NB) phenotype. The presence of MYCN specific T-cells in patients with neuroblastoma indicate that MYCN is a promising target for active immunity approaches and Interleukin 21 (IL-21) is an attractive adjuvant for a DNA vaccine with regard to its ability to induce cytotoxic T cell…
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Zitierempfehlung
D Reker, A Stermann, N Huebener, F Westermann, N Siebert, HN Lode (2011) Development of an IL-21 enhanced MYCN-DNA vaccine for anti-neuroblastoma immunotherapy. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0031-1277095
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