CareLit · DOI-Nachweis · Klinische Pädiatrie
4-HPR (fenretinide) sensitizes human neuroblastoma cells for ch14.18-mediated NK cell and complement killing
DOI 10.1055/s-0031-1277097
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Nachweis in CareLit
Autor:innenA Shibina, D Seidel, S Somanchi, DA Lee, HN Lode, CP Reynolds, N Huebener
ZeitschriftKlinische Pädiatrie
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: 4-HPR is a synthetic retinoid that induces apoptosis in cancer cells mainly through the accumulation of ceramides. We tested the hypothesis whether 4-HPR and ch14.18 would work additively in NK cell-mediated killing when applied in combination. Methods: 6 GD2+, drug-resistant human NB cell lines were treated with 4-HPR and analyzed for GD2 expression by flow cytometry (FC) and in ADCC and CDC assays me…
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Zitierempfehlung
A Shibina, D Seidel, S Somanchi, DA Lee, HN Lode, CP Reynolds, N Huebener (2011) 4-HPR (fenretinide) sensitizes human neuroblastoma cells for ch14.18-mediated NK cell and complement killing. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0031-1277097
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