CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
PTBP1 and translation of diabetogenic viruses in beta cells
DOI 10.1055/s-0031-1277265
Bibliografische Angaben
Nachweis in CareLit
Autor:innenKP Knoch
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Glucose entry in the pancreatic beta cell triggers insulin secretion and the rapid biosynthesis of insulin granules (ISGs). We have shown that glucose and cAMP independently promote the nucleocytoplasmic translocation of polypyrimidine tract-binding protein (PTBP1) in beta cells (Knoch et al., 2004 and 2006). Cytosolic PTBP1 binds the mRNAs encoding ISG proteins, thus enhancing their stability and translation. PTBP1…
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Zitierempfehlung
KP Knoch (2011) PTBP1 and translation of diabetogenic viruses in beta cells. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0031-1277265
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