CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Modulating glucocorticoid receptor translocation in the liver – therapeutic relevance for HDAC6?
DOI 10.1055/s-0031-1277340
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Nachweis in CareLit
Autor:innenR Winkler, M Clemenz, M Bloch, A Foryst-Ludwig, G Matthias, O Truee, P Matthias, U Kintscher
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
In vitro the histone deacetylase 6 (HDAC6) has been shown to be a major deacetylase of heat shock protein 90 (HSP90). It is mediating glucocorticoid receptor (GR) ligand interaction since the correct folding of the GR as HSP90 client protein depends on HSP90 acetylation status. We could recently show that HDAC6 deficiency results in an attenuation of dex-induced whole-body glucose intolerance as well as insulin resi…
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Zitierempfehlung
R Winkler, M Clemenz, M Bloch, A Foryst-Ludwig, G Matthias, O Truee, P Matthias, U Kintscher (2011) Modulating glucocorticoid receptor translocation in the liver – therapeutic relevance for HDAC6?. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0031-1277340
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