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Three-year exenatide therapy, followed by a 4-week off-drug period, had a sustainable effect on β-cell disposition index in metformin treated patients with type 2 diabetes

M Bunck, A Corner, B Eliasson, R Heine, R Shaginian, U Smith, H Yki-Jarvinen, O Bachmann, M Diamant · Diabetologie und Stoffwechsel · Ausgabe 05/2011

DOI 10.1055/s-0031-1277490

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Autor:innenM Bunck, A Corner, B Eliasson, R Heine, R Shaginian, U Smith, H Yki-Jarvinen, O Bachmann, M Diamant
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben

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Introduction: Previously we showed that exenatide (Ex) improved β-cell function after 1-yeartreatment, relative to insulin glargine (IG), with a similar glucose lowering effect. This effect was not sustained after a 4-week off-drug period. Here we report theeffects of an additional 2 years of therapy. Methods: Metformin treated patients with type 2 diabetes were randomized to Ex (n=36) or IG (n=33) (mean±SD: age 59±…

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M Bunck, A Corner, B Eliasson, R Heine, R Shaginian, U Smith, H Yki-Jarvinen, O Bachmann, M Diamant (2011) Three-year exenatide therapy, followed by a 4-week off-drug period, had a sustainable effect on β-cell disposition index in metformin treated patients with type 2 diabetes. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0031-1277490

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