CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Increased cysteine-protease activity in fecal supernatants from constipated IBS-C patients leads to occludin enzymatic degradation in colonic mucosa
DOI 10.1055/s-0031-1278504
Bibliografische Angaben
Nachweis in CareLit
Autor:innenR Róka, A Annaházi, V Bezirard, H Eutamene, L Ferrier, P Ducrotté, O Inczefi, A Rosztóczy, G Ollé, K Gecse, T Molnár, T Piche, V Theodorou, L Bueno, T Wittmann
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe05/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and aims: We have previously demonstrated that (i) fecal cysteine-protease (CP) activity is elevated only in constipated IBS (IBS-C) patients among IBS subtypes and (ii) repeated mucosal exposure to this luminal factor enhances colorectal sensitivity and increases intestinal permeability in mice via the degradation of occludin. We aimed to further explore if IBS-C fecal supernatant is able to degrade the…
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Zitierempfehlung
R Róka, A Annaházi, V Bezirard, H Eutamene, L Ferrier, P Ducrotté, O Inczefi, A Rosztóczy, G Ollé, K Gecse, T Molnár, T Piche, V Theodorou, L Bueno, T Wittmann (2011) Increased cysteine-protease activity in fecal supernatants from constipated IBS-C patients leads to occludin enzymatic degradation in colonic mucosa. Zeitschrift für Gastroenterologie (05). https://doi.org/10.1055/s-0031-1278504
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