CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Specific therapeutic targeting of malignancies of the liver by transient depletion of adenosine triphosphates
DOI 10.1055/s-0031-1285444
Bibliografische Angaben
Nachweis in CareLit
Autor:innenT Weiland, K Klein, M Zimmermann, T Speicher, S Venturelli, A Berger, H Bantel, A Königsrainer, M Schenk, TS Weiss, A Wendel, M Schwab, M Bitzer, UM Lauer
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background & aims: Despite its high potency, TNF's current use in medical oncology is restricted since effective doses leading to profound hepatotoxicity. Interestingly, TNF-induced cytotoxicity is known to be a highly ATP-dependent process. In primary murine hepatocytes it was recognized that fructose transiently depletes ATP which is due to a distinct enzyme configuration being specific for hepatocytes leading to…
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Zitierempfehlung
T Weiland, K Klein, M Zimmermann, T Speicher, S Venturelli, A Berger, H Bantel, A Königsrainer, M Schenk, TS Weiss, A Wendel, M Schwab, M Bitzer, UM Lauer (2011) Specific therapeutic targeting of malignancies of the liver by transient depletion of adenosine triphosphates. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0031-1285444
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