CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
In vivo RNAi screening identifies new mediators of p53 independent tumor suppressive functions of p19Arf in the liver
DOI 10.1055/s-0031-1285576
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Autor:innenD Dauch, T Wüstefeld, TW Kang, A Hohmeyer, R Rudalska, L Hoenicke, P Schirmacher, T Longerich, M Manns, L Zender
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The sources of hepatocellular carcinoma are liver progenitor cells or hepatocytes. Interestingly, we observed differences between progenitor cell- and hepatocyte- derived hepatocellular carcinomas in mice. Oncogenic Nras (NrasG12V) efficiently triggers hepatocellular carcinomas derived from p53-/- liver progenitor cells, however almost no tumor growth is observed, when NrasG12V is delivered into p53-/- hepatocytes.…
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Zitierempfehlung
D Dauch, T Wüstefeld, TW Kang, A Hohmeyer, R Rudalska, L Hoenicke, P Schirmacher, T Longerich, M Manns, L Zender (2011) In vivo RNAi screening identifies new mediators of p53 independent tumor suppressive functions of p19Arf in the liver. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0031-1285576
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