CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Protein-protein interactions of the p53 family with the Bcl-2 family in hepatocellular carcinoma
DOI 10.1055/s-0031-1285581
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Autor:innenLC König, M Meinhard, C Sandig, MH Bender, A Lovas, W Stremmel, M Müller
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Bcl-2 family proteins serve as critical regulators in apoptosis, either promoting or inhibiting cell death via the mitochondrial apoptosis signaling pathway. Wildtype p53 promotes apoptosis via transcription-dependent and transcription-independent mechanisms. The latter may be mediated by direct translocation of p53 to the mitochondria where it leads to outer mitochondrial membrane permeabilization (OMMP) by forming…
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Zitierempfehlung
LC König, M Meinhard, C Sandig, MH Bender, A Lovas, W Stremmel, M Müller (2011) Protein-protein interactions of the p53 family with the Bcl-2 family in hepatocellular carcinoma. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0031-1285581
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