CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Chemotherapy-induced apoptosis in pancreatic cancer with mutant p53 involves p73 and is mediated via the extrinsic and the intrinsic pathway
DOI 10.1055/s-0031-1285643
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Autor:innenM Soboletzki, S Staemmler, N Joschko, A Lovas, W Stremmel, M Müller
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Pancreatic cancer is associated with low responsiveness to conventional chemotherapies. The development of up to 70% of pancreatic carcinomas has been shown to be associated with a loss of p53 function. Like p53, TAp63 and TAp73 activate genes exerting roles in different steps of the apoptosis signalling program. The dominant-negative isoforms of p63 and p73 (deltaNp63, deltaNp73) can oppose the transa…
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Zitierempfehlung
M Soboletzki, S Staemmler, N Joschko, A Lovas, W Stremmel, M Müller (2011) Chemotherapy-induced apoptosis in pancreatic cancer with mutant p53 involves p73 and is mediated via the extrinsic and the intrinsic pathway. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0031-1285643
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