CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Effect of complement 5a receptor (C5R1) deficiency on liver fibrosis in mice
DOI 10.1055/s-0031-1285729
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Autor:innenK Hochrath, SN Weber, S Hillebrandt, U Pieper-Fürst, V Schmitz, S Huss, HP Fischer
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Previously we refined a quantitative trait locus that confers susceptibility to hepatic fibrosis in inbred mice and showed, that the gene encoding complement factor C5 underlies this fibrogenic locus in mice (Nat Genet 2005). C5R1 is a G protein-coupled receptor that specifically binds C5a, the potent proinflammatory fragment of C5. Our aim now was to dissect whether the profibrogenic effects of C5 are m…
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Zitierempfehlung
K Hochrath, SN Weber, S Hillebrandt, U Pieper-Fürst, V Schmitz, S Huss, HP Fischer (2011) Effect of complement 5a receptor (C5R1) deficiency on liver fibrosis in mice. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0031-1285729
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