CareLit · DOI-Nachweis · Klinische Pädiatrie
Bortezomib primes glioblastoma including glioblastoma stem cells for TRAIL by increasing tBid stability and mitochondrial apoptosis
DOI 10.1055/s-0031-1292586
Bibliografische Angaben
Nachweis in CareLit
Autor:innenT Unterkircher, S Cristofanon, S Fulda
ZeitschriftKlinische Pädiatrie
Ausgabe11/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Glioblastoma is refractory to current treatment approaches calling for novel strategies. One emerging option is proteasome inhibition as some antitumor activity in glioblastoma has recently been shown. Here, we report that the proteasome inhibitor Bortezomib primes glioblastoma cells including glioblastoma stem cells to TRAIL-induced apoptosis in vitro and in vivo by increasing tBid stability and facilitating mitoch…
Zitieren
Zitierempfehlung
T Unterkircher, S Cristofanon, S Fulda (2011) Bortezomib primes glioblastoma including glioblastoma stem cells for TRAIL by increasing tBid stability and mitochondrial apoptosis. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0031-1292586
Mit CareLit weiterarbeiten