CareLit · DOI-Nachweis · Klinische Pädiatrie
Cdk-inhibition as putative new glioblastoma therapy
DOI 10.1055/s-0031-1292587
Bibliografische Angaben
Nachweis in CareLit
Autor:innenCP Dohm, P Hülper, P Kermer, H Strik, JH Weishaupt
ZeitschriftKlinische Pädiatrie
Ausgabe11/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Glioblastoma multiforme is characterized by a high invasive and infiltrative tumor growth. Roscovitine, a cyclin dependent kinase (cdk)-inhibitor, is already used in clinical trials against cancer of different origin. It not only inhibits cell cycle dependent cdks (2, 7, 8 and 9) but also cdk5, which plays a role in cell migration. This dual activity makes roscovitine an interesting putative candidate for glioblasto…
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Zitierempfehlung
CP Dohm, P Hülper, P Kermer, H Strik, JH Weishaupt (2011) Cdk-inhibition as putative new glioblastoma therapy. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0031-1292587
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