CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis
DOI 10.1055/s-0031-1295732
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Autor:innenR Barikbin, D Neureiter, JW Wirth, A Erhardt, D Schwinge, J Kluwe, C Schramm, G Tiegs, G Sass
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background: Heme oxygenase 1 (HO–1) has been shown to protect mice from acute hepatitis. We now investigated effects of HO–1 induction in a mouse model of chronic liver inflammation (Mdr2 knockout; Mdr2ko; FVB.129P2-Abcb4tm1Bor) with respect to effects on immune cell infiltration and activity and fibrosis formation. Methods: HO–1 was induced in Mdr2ko mice for 7 consecutive weeks. Liver damage was monitored by alani…
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Zitierempfehlung
R Barikbin, D Neureiter, JW Wirth, A Erhardt, D Schwinge, J Kluwe, C Schramm, G Tiegs, G Sass (2012) Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295732
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