CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Neutralization of Bone Morphogenetic Protein (BMP)–9 in mouse liver reduces CCl–4 mediated fibrogenesis
DOI 10.1055/s-0031-1295734
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Nachweis in CareLit
Autor:innenK Breitkopf-Heinlein, Q Li, MJ Goumans, E Wiercinska, P ten Dijke, S Dooley
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
BMP9, a member of the TGFβ family of cytokines, is mainly expressed in liver. We therefore investigated responses to BMP9 in vitro in hepatic stellate cells (HSC) and hepatocytes (HC) and in vivo. In vascular endothelial cells and most likely in other cell types as well, BMP9 exerts its effects by binding to, and signaling via ALK1.HSC/HC were isolated from mice livers by collagenase digestion and were analyzed duri…
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Zitierempfehlung
K Breitkopf-Heinlein, Q Li, MJ Goumans, E Wiercinska, P ten Dijke, S Dooley (2012) Neutralization of Bone Morphogenetic Protein (BMP)–9 in mouse liver reduces CCl–4 mediated fibrogenesis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295734
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