CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis
DOI 10.1055/s-0031-1295737
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Autor:innenB Czech, D Valletta, M Saugspier, K Dettmer, A Stevens, C Dorn, TS Weiss, A Bosserhoff, P Oefner, C Hellerbrand
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Methylthioadenosine phosphorylase (MTAP) the rate-limiting enzyme in the methionine and adenine salvage pathway catalyzes the phosphorylation of 5´-deoxy–5´-(methylthio)adenosine (MTA) which is a by-product of polyamine synthesis. The aim of this study was to assess MTAP expression and function during the progression of chronic liver disease. Methods and Results: MTAP mRNA and protein were reduced in the murine bile…
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Zitierempfehlung
B Czech, D Valletta, M Saugspier, K Dettmer, A Stevens, C Dorn, TS Weiss, A Bosserhoff, P Oefner, C Hellerbrand (2012) Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295737
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