CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis
DOI 10.1055/s-0031-1295761
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Autor:innenJU Marquardt, T Maass, M Krupp, F Staib, T Gaiser, JB Andersen, PR Galle, SS Thorgeirsson, A Teufel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
The role of platelet-derived growth factor (PDGF) family for the perpetuation of liver fibrogenesis and stellate cell activation is well documented. Increasing PDGF-b levels are observed in patients with severe liver fibrosis. We have recently demonstrated that forced expression of PDGF-b in hepatocytes results in spontaneous liver fibrosis, but the exact molecular mechanisms and signaling pathways remain unknown. T…
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Zitierempfehlung
JU Marquardt, T Maass, M Krupp, F Staib, T Gaiser, JB Andersen, PR Galle, SS Thorgeirsson, A Teufel (2012) Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295761
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