CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Extracellular matrix induced signaling and TGF-β regulate Caveolin–1 expression in hepatocytes
DOI 10.1055/s-0031-1295763
Bibliografische Angaben
Nachweis in CareLit
Autor:innenC Meyer, Y Liu, F Schindler, J Dzieran, S Dooley
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
A major obstacle for the use of primary hepatocytes in research and drug testing is their tendency to dedifferentiate towards a mesenchymal phenotype during culture. This process is driven by integrin/FAK/Src signaling cascades, which leads to the upregulation of fibroblastoid markers, such as vimentin and N-Cadherin. Caveolin–1 is involved in endocytic processes as well as in the regulation of diverse signaling cas…
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Zitierempfehlung
C Meyer, Y Liu, F Schindler, J Dzieran, S Dooley (2012) Extracellular matrix induced signaling and TGF-β regulate Caveolin–1 expression in hepatocytes. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295763
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