CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Mapping differential susceptibility of primary hepatocytes to TGF-β in the BXD population of recombinant inbred mouse lines
DOI 10.1055/s-0031-1295766
Bibliografische Angaben
Nachweis in CareLit
Autor:innenR Müllenbach, R Hall, S Dooley, F Lammert
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: TGF-β is the central pro-fibrogenic cytokine in liver, and exerts autocrine effects on neighbouring hepatocytes as well as attracting and activating myofibroblasts. We suspect that differential sensitivity to autocrine TGF-β signalling might be a factor underlying the susceptibility to developing fibrosis in various aetiologies. Hypothesis: Genetic variants causing different hepatocellular sensitivity to TGF-β…
Zitieren
Zitierempfehlung
R Müllenbach, R Hall, S Dooley, F Lammert (2012) Mapping differential susceptibility of primary hepatocytes to TGF-β in the BXD population of recombinant inbred mouse lines. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295766
Mit CareLit weiterarbeiten