CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration
DOI 10.1055/s-0031-1295775
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Autor:innenF Pinna, S Tuncay, LA D'Alessandro, R Gauges, M Bissinger, U Klingmuller, U Kummer, P Schirmacher, K Breuhahn
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
During liver regeneration, initiation and termination of hepatocyte proliferation is tightly regulated by a defined subset of secreted factors. The cytokine tumor necrosis factor (TNFα) is specifically secreted by Kupffer cells very early in the priming phase of regeneration and promotes DNA synthesis and cell cycle progression of quiescent hepatocytes by activation of the NF-κB pathway. However, little is known abo…
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Zitierempfehlung
F Pinna, S Tuncay, LA D'Alessandro, R Gauges, M Bissinger, U Klingmuller, U Kummer, P Schirmacher, K Breuhahn (2012) Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295775
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