CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Evidence for differential modulation of liver fibrogenesis by selective inhibition of the chemokine receptor CCR1 in a toxic model but not Abcb4-/- mice
DOI 10.1055/s-0031-1295789
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Autor:innenSN Weber, A Bohner, R Goebel, I Adrian, F Lammert, F Grünhage
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Recently recruitment of peripheral blood monocytes via CCR2 stimulation has been shown to induce liver fibrosis in a toxic mouse model of liver fibrosis. In humans, monocyte recruitment is also influenced by CCR1 signalling. Inhibition of CCR1 signalling by a specific non-peptide inhibitor (BX471) reduces kidney fibrosis after unilateral ureteral obstruction. However, currently it remains unclear whether selec…
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Zitierempfehlung
SN Weber, A Bohner, R Goebel, I Adrian, F Lammert, F Grünhage (2012) Evidence for differential modulation of liver fibrogenesis by selective inhibition of the chemokine receptor CCR1 in a toxic model but not Abcb4-/- mice. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295789
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