CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Insulin aggravates free fatty acid-induced hepatocyte cell death by activation of CD95 death receptor pathways in liver
DOI 10.1055/s-0031-1295796
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Autor:innenR Reinehr, A Sommerfeld, D Häussinger
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Free fatty acids (FFA) induce lipoapoptosis in hepatocytes in a JNK-dependent but death receptor-independent way.1 Insulin has been reported to induce EGFR activation in liver.2 Since JNK-dependent and EGFR-mediated CD95-Tyr-P is a crucial step in CD95 activation,3 the aim of the study was to elucidate whether addition of insulin may aggravate FFA-induced cell death by activation of CD95. Methods: Stud…
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Zitierempfehlung
R Reinehr, A Sommerfeld, D Häussinger (2012) Insulin aggravates free fatty acid-induced hepatocyte cell death by activation of CD95 death receptor pathways in liver. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295796
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