CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations
DOI 10.1055/s-0031-1295800
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJ Böttger, J Schütte, K Benz, C Freudigmann, B Hagmeyer, C Höppner, H Becker, P Röhnert, M Stelzle, R Gebhardt
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
PRESENTLY used in vitro test systems for drug and toxicity investigations lack the complexity of the liver and reduce test systems solely to hepatocytes or random co-cultures with non-parenchymal cells. Unfortunately, hepatocytes rapidly lose their typical morphology and the expression of metabolizing enzymes, which leads to cell phenotypes that differ from those found in the human physiology. This unstable phenotyp…
Zitieren
Zitierempfehlung
J Böttger, J Schütte, K Benz, C Freudigmann, B Hagmeyer, C Höppner, H Becker, P Röhnert, M Stelzle, R Gebhardt (2012) A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295800
Mit CareLit weiterarbeiten