CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Src kinase Fyn mediates hyperosmolarity-induced Mrp2- and Bsep-retrieval from the canalicular membrane in a cortactin dependent way
DOI 10.1055/s-0031-1295823
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Autor:innenR Reinehr, M Cantore, A Sommerfeld, M Becker, D Häussinger
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: Hyperosmolarity induces Mrp2-/Bsep-retrieval from the canalicular membrane leading to cholestasis.1,2 The underlying signaling events remained unclear. Methods: Rat livers were perfused with either normo- (305mOsm) or hyperosmolarity (385mOsm) following Mrp2-/Bsep-staining and analyzation of transporter localization. Bile flow was measured by biliary excretion of CDNB-glutathione conjugate in perfused…
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Zitierempfehlung
R Reinehr, M Cantore, A Sommerfeld, M Becker, D Häussinger (2012) Src kinase Fyn mediates hyperosmolarity-induced Mrp2- and Bsep-retrieval from the canalicular membrane in a cortactin dependent way. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295823
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