CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The proximal TGR5 C-Terminus is required for membrane localization
DOI 10.1055/s-0031-1295830
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Autor:innenL Spomer, V Keitel, D Häussinger
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
TGR5 (Gpbar–1) is a plasma membrane-bound bile acid receptor, which is coupled to a stimulatory G-protein. The structure of TGR5 is unknown and it remains elusive which amino acids are important for receptor localization and function. Based on previous findings [1] that a C-terminal truncation variant (Q296) is retained in the endoplasmic reticulum and therefore nonfunctional, we tried to identify motifs in the TGR5…
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Zitierempfehlung
L Spomer, V Keitel, D Häussinger (2012) The proximal TGR5 C-Terminus is required for membrane localization. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295830
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