CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Viral infection sensitizes hepatocytes towards TNF-induced apoptosis
DOI 10.1055/s-0031-1295886
Bibliografische Angaben
Nachweis in CareLit
Autor:innenMK Frings, D Stabenow, M Odenthal, M Heikenwälder, H Kashkar, M Krönke, PA Knolle
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
We identified a novel mechanism by which CD8 T cells selectively eliminate virus-infected hepatocytes without direct MHC class I recognition. This mechanism involves TNF secreted by CD8 T cells, which selectively induces death of infected hepatocytes. Triggering of the TNF receptor can induce both, pro-survival pathways via NFkB activation, and apoptotic pathways involving generation of ROS and caspase activation. T…
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Zitierempfehlung
MK Frings, D Stabenow, M Odenthal, M Heikenwälder, H Kashkar, M Krönke, PA Knolle (2012) Viral infection sensitizes hepatocytes towards TNF-induced apoptosis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295886
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