CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
HCV core protein interferes with Smad1 and Smad3 dependent TGF-β signaling in HCC cells
DOI 10.1055/s-0031-1295908
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Autor:innenJ Fabian, J Dzieran, S Dooley, NM Meindl-Beinker
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
TGF-β plays a pivotal role in cell signaling in liver. In healthy tissue and early stages of liver diesease, TGF-β signaling controls apoptosis, cell proliferation and differentiation, thereby acting as a tumor suppressor. In HCV-infected patients, TGF-β levels are upregulated. We investigated TGF-β signaling in Huh–7 cells stably overexpressing HCV core protein, or carrying the empty vector as a control. Transcript…
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Zitierempfehlung
J Fabian, J Dzieran, S Dooley, NM Meindl-Beinker (2012) HCV core protein interferes with Smad1 and Smad3 dependent TGF-β signaling in HCC cells. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295908
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