CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
HLA-B27 has a dominant role in restricting strong CD8+ T cell responses and driving viral escape in hepatitis B virus infection
DOI 10.1055/s-0031-1295918
Bibliografische Angaben
Nachweis in CareLit
Autor:innenMM Kiraithe, K Nitschke, R Thimme, C Neumann-Haefelin
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Important insights into the immunobiology of HIV and HCV infection have been derived from the study of protective HLA-B27 restricted CD8+ T cell responses in these two important human viral infections. Indeed, immunodominant HLA-B27 restricted CD8+ T cell epitopes have been identified in both infections. Viral escape from these two protective epitopes is the main mechanism of T cell failure in the few HLA-B27+ patie…
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Zitierempfehlung
MM Kiraithe, K Nitschke, R Thimme, C Neumann-Haefelin (2012) HLA-B27 has a dominant role in restricting strong CD8+ T cell responses and driving viral escape in hepatitis B virus infection. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295918
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