CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Hepatic toll-like receptors can be activated by application of siRNAs in vivo via MyD88-dependent pathways which can be controlled by chemical ribose modifications of the siRNA backbone
DOI 10.1055/s-0031-1295929
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Autor:innenCI Real, R Bröring, M John, K Jahn-Hofmann, L Ickenstein, K Kleinehr, G Gerken, JF Schlaak
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: siRNAs are being developed for the therapeutic use in liver cancer, viral hepatitis, metabolic disorders and others. We have previously shown that chemical modifications of siRNAs suppress immunologically mediated off-target effects in vitro and in vivo. Here, we assessed efficacy and the Toll-like receptor dependent immune-stimulatory effects of differently modified siRNAs in vivo. Methods: Nanolipid-…
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Zitierempfehlung
CI Real, R Bröring, M John, K Jahn-Hofmann, L Ickenstein, K Kleinehr, G Gerken, JF Schlaak (2012) Hepatic toll-like receptors can be activated by application of siRNAs in vivo via MyD88-dependent pathways which can be controlled by chemical ribose modifications of the siRNA backbone. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295929
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