CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A
DOI 10.1055/s-0031-1295947
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Nachweis in CareLit
Autor:innenT Von Hahn, C Schiene-Fischer, E Steinmann, CP Strassburg, H Wedemeyer, C Sarrazin, T Müller, T Berg, MP Manns, T Pietschmann, S Ciesek
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The hepatitis C virus (HCV), a world-wide leading cause of cirrhosis and liver cancer, utilizes a number of host encoded cofactors to infect and replicate in human hepatocytes. Among these, cyclophilin A (CypA) stands out because it is critical for viral replication and CypA inhibitors like alisporivir are currently the most advanced anti-HCV compounds with a host encoded target in clinical development. Several gene…
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Zitierempfehlung
T Von Hahn, C Schiene-Fischer, E Steinmann, CP Strassburg, H Wedemeyer, C Sarrazin, T Müller, T Berg, MP Manns, T Pietschmann, S Ciesek (2012) Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295947
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